In 2007 Hussie launched the website MS Paint Adventures to host comics he had created as forum games. The most popular of Hussie's works is the webcomic Homestuck which ran from 2009 to 2016. It tells the story of a group of four kids who play a computer game called Sburb and inadvertently cause the end of the world.
Homestuck was on the reading list of Nick Mathewson, creator of Tor, and one of Foreign Policy magazine's top 100 global thinkers of 2012. Homestuck was also cited as evidence that the "recent rejuvenation of adventure games has legs."
Homestuck has been compared to Ulysses because of the complex and densely worded storytelling the series often utilizes.
Despite his popularity, Hussie has managed to maintain quite a bit of secrecy regarding his personal life. His exact age is not generally known. References to dates made in his Blogspot blog and Formspring account suggest that he was born in 1979. He currently lives in western Massachusetts.
He graduated from Temple University with a degree in computer science. He is a managing member of the company What Pumpkin, LLC.
- Andrew Hussie, with Jan Van dem Hemel, created many parody videos of Star Trek: The Next Generation from 2006 to 2009 or 2010.
- Webcomics by Andrew Hussie
- Team Special Olympics
- MS Paint Adventures
- Bard Quest (June 12, 2007 to July 6, 2007)
- Problem Sleuth (March 10, 2008 to April 7, 2009)
- Homestuck (April 13, 2009 to April 13, 2016)
- Sweet Bro and Hella Jeff
- Published books
- Whistles, Book One (The Starlight Calliope) (out of print, available online) ISBN 978-1-59362-073-8
- Problem Sleuth (Five volumes, which cover all 22 chapters)
- Homestuck (So far only three volumes, which cover Acts 1, 2, and 3, respectively)
- Sweet Bro and Hella Jeff ISBN 978-1936561-03-2
- Dinosaur Comics: Everybody Knows Failure is Just Success Rounded Down ISBN 978-1-936561-90-2
- Video game projects
- Namco High (2013)