Rouse was the son of of Rouse Lench, Worcestershire who was MP in 1626. He matriculated at on 20 October 1626 and was awarded BA from on 31 January 1628. Also in 1628, he entered . He was created on 23 July 1641.

Rouse was added to the Committee for Worcestershire in 1645 and was in 1648. In 1654, he was elected for in the . He was an assessment commissioner in 1656 and was also Custos Rotulorum in 1656.

In 1660, Rouse was elected MP for in the . He became a on 10 July 1660.

Rouse died at the age of 67 and was buried at Rouse Lench,where there is an monument.

Rouse married firstly Jane Ferrers daughter of Sir John Ferrers of Tamworth Castle, secondly Frances Murray daughter of David Murray and thirdly Ann.