Besides studying with his father, he was also a disciple of Melattur Sama Dikshitar. Maharajapuram Santhanam was also a distinguished composer. He wrote many songs on Lord and Kanchi Shankaracharya, His Holiness Sri Swamigal (Maha Periyavar). He was the Principal of Ramanathan College in Sri Lanka. Later he came and settled in . The songs which were popularised by Maharajapuram Santhanam are,"Bho Shambo" (), "Madhura Madhura" (Bagheshri), both composed by Swami Dayananda Saraswati, "Unnai Allal" ( ), "Sadha Nin Padhame gathi, Varam onnru" (), "Srichakra Raja" (Ragamalika), "Nalinakaanthimathim" (Ragamalika),"Ksheerabdi kannike" (Ragamalika) among others. The Maharajapuram Santhanam Day is celebrated on the 3rd of December every year.

He died in a car accident on June 24, 1992. His sons Maharajapuram S. Srinivasan, Maharajapuram S. Ramachandran, and his primary disciple Dr. R. Ganesh are now carrying on his musical tradition.

His other most popular songs are : "" () and "Govinda ninna". His rendition of "Vilayada ithu nerama muruga" was without parallel. His renditions were full of .

In Chennai, Griffith Road in T.Nagar was renamed as 'Maharajapuram Santhanam Salai' in honor of Maharajapuram Santhanam, by Karunanidhi and Stalin. The street has the famous Krishna Gana Sabha and Muppathamman Temple.

Awards and Titles

  • - 1990
  • from the - 1989
  • award - 1984
  • award by Tamil Nadu Government
  • "Sangeetha Sudhakara" by the Yoga vedanta University at
  • "Gana Kalanidhi" by of
  • "Sangitha Sagaramritha Varshi" by of .
  • A former "Asthana Vidwan" of the , , Venkatachalapathi Temple and the Ashrama