Kassandra can refer to:
- Cassandra, in Greek mythology
- 114 Kassandra, an asteroid
- Cassandra (novel), a book written by the East German author Christa Wolf (published 1983)
- Cassandreia, an ancient city and adjoining isthmus in Chalcidice, Greece
- Kassandra, Chalkidiki, a municipality on the above isthmus
- Kassandra (TV series), a Venezuelan telenovela about a gypsy maiden marrying into a rich family
- Kassandra, a composition by Iannis Xenakis.