Mephisto or Mephistopheles is one of the chief demons of German literary tradition.
Mephisto or Mephistopheles may also refer to:
In film and television
- Mephisto (1981 film), a German-Hungarian film based on Klaus Mann's novel Mephisto
- Méphisto (1930 film), a French film
- Dr. Alphonse Mephisto, a mad scientist in the South Park TV series
- Mephistopheles (Xena), a villain in the Xena: Warrior Princess TV series
- Mephisto, a character on the Australian television series, Double the Fist
- Mephisto Pheles, a son of Satan in the manga/anime Blue Exorcist
- Mephisto (automaton), a chess-playing pseudo-automaton
- Mephisto (chess computer), a line of chess computers sold by Hegener & Glaser
- Mephisto (Diablo), one of the "Prime Evils" in the computer games Diablo, Diablo II and Diablo III
- Mephistopheles (Dungeons & Dragons), an archdevil in the Dungeons & Dragons role-playing game from TSR, Inc.
- Mr. Mephisto, an early video game
In literature and publications
- Mephistopheles, the devil in Goethe's Faust
- Mephisto (comics), a supervillain in the Marvel Comics universe
- Mephisto (novel), a novel by Klaus Mann
- Mr. Mistoffelees, a black cat in T.S. Eliot's Old Possum's Book of Practical Cats and in the musical Cats
- Mefisto, a novel by John Banville
- Mephisto (magazine), a Japanese literary magazine
- Mefisto (band), a Swedish black metal band
- Mephisto Waltzes (1859-1885), waltzes by Franz Liszt
- Mefistofele (1868), an opera by Italian composer Arrigo Boito
- Mephisto, musician and songwriter for Demonic Resurrection
- "Mephisto", a song by Moonspell from the 1996 album Irreligious
- "Mephisto", a song by Klaus Schulze from the 2005 album Moonlake
- Mefisto, a pseudonym of the composer and musician Chris Cooley (artist)
- "Mephistopheles", a song by Deicide from the album Deicide
- "The Mephistopheles of Los Angeles", a song by Marilyn Manson from the 2015 album The Pale Emperor
- "March of Mephisto", a song by Kamelot from the 2005 album "The Black Halo"
- "Down, Down, Down to Mephisto's Cafe", a song by Streetlight Manifesto from the 2007 album "Somewhere in the Between"
- Mephisto (wrestler), a Mexican wrestler