It is published in 11 cities across Mexico, including Monterrey, Mexico City, Guadalajara, León, Pachuca, Puebla, Villahermosa, Tampico, Torreón, Toluca, and Xalapa. In each local edition they include local content and national news developed by the media group, not only from their newspaper reporters, but additionally from the radio and television stations owned by Multimedios.
It started in Monterrey as Diario de Monterrey, and expanded to additional cities in the first decade of the twenty-first century.
During elections, Milenio publishes the acclaimed María de las Heras poll, that was the only poll in Mexico to predict the victory of Vicente Fox in 2000.
The newspaper additionally publishes a biweekly magazine distributed nationwide, and have their own 24-hour news channel.
The newspaper was criticised for publishing a daily poll which gave President Enrique Peña Nieto an 18-point lead over Andrés Manuel López Obrador 5 days before the election, while the real difference was 6.46%. Ciro Gómez Leyva printed a public apology, adding that they would "retire from electoral polling."