Mizuno might refer to:
- Mizuno (surname)
- Mizuno Corporation, a Japanese sportswear and sports equipment manufacturer
- Mizuno (daimyo), a political family in Japanese history
- Mizuno Shinryu, rocket-powered late-WWII aircraft design.
- Asteroid 4541 Mizuno discovered by Yoshikane Mizuno
- Mizuno Classic, an annual golf tournament for professional female golfers on the United States LPGA Tour