Safire may refer to:

  • Sa-Fire, a vocalist
  • Safire (illusionists), an illusion act
  • William L. Safire, an American journalist and speechwriter
  • Safire (software), a web application framework for the iPhone
  • SAFIRE, Submillimeter and Far-InfraRed Experiment (SAFIRE) on the SOFIA airborne observatory is an imaging Fabry-Perot spectrometer operating at wavelengths between 100μm and 700μm.[2]