Safire may refer to:
- Sa-Fire, a vocalist
- Safire (illusionists), an illusion act
- William L. Safire, an American journalist and speechwriter
- Safire (software), a web application framework for the iPhone
- SAFIRE, Submillimeter and Far-InfraRed Experiment (SAFIRE) on the SOFIA airborne observatory is an imaging Fabry-Perot spectrometer operating at wavelengths between 100μm and 700μm.