2001–10: Early career
Hampton has appeared in several television series, such as Shameless, Reba, Popular, Scrubs, Criminal Minds, Related, and Miami Medical. She has also had roles in the movies: The Mostly Unfabulous Social Life of Ethan Green, The Hanged Man, and You Again.
She had her face modeled for the video game Left 4 Dead 2.
In Summer 2010, Hampton was cast as a series regular on the Showtime dramedy Shameless as Veronica Fisher, a role for which she has received critical acclaim. On February 1, 2012, the series was renewed for a third season, which began shooting on June 27, 2012 and premiered on Sunday, January 13, 2013. On January 29, 2013, Showtime renewed Shameless for a fourth season, which premiered on January 12, 2014. On February 18, 2014, Showtime renewed Shameless for a fifth season, which premiered on January 11, 2015. On January 12, 2015, Showtime renewed Shameless for a sixth season.
Hampton is married to producer Daren Dukes. They have two children, daughter Cai MyAnna and son Daren.
|2004||Girls' Lunch||Short film|
|2005||The Mostly Unfabulous Social Life of Ethan Green||Charlotte|
|2007||The Hanged Man||X-Factor|
|2012||Hot and Bothered||Alex||Short film|
|2013||They Die by Dawn||Pretty Woman||Short film|
|2013||Things Never Said||Kalindra Stepney|
|2001||Electra Woman and Dyna Girl||Daisy|
|2001||Reba||Marci||Episode: "The Steaks Are High"|
|2002||Strong Medicine||Tracy Saunders||Episode: "Family Stories"|
|2004||Scrubs||Episode: "My Best Moment"|
|2006||Pepper Dennis||Darcine||Episode: "True Love is Dead"|
|2010||Miami Medical||Dr. Graceffa||6 episodes|
|2011–present||Shameless||Veronica Fisher||Main role|
|2012||Criminal Minds||Cindi Burns||Episode: "The Company"|