Sixer or Sixers may refer to:

  • Sixer, a punk band from Richmond, Virginia, United States
  • Sixer (film), a 2007 Indian film
  • Philadelphia 76ers, a professional basketball team in Philadelphia, Pennsylvania, United States
  • Fort Worth Sixers, a National Indoor Football League franchise in the United States
  • Sydney Sixers, an Australian cricket franchise
  • Southern Sixers, mountains in the southern United States which are at least six thousand feet tall
  • Stephen Kellogg and the Sixers, an American rock band
  • The members of the sixth pilgrimage to Terra Nova, the settlement in the U.S. TV series of the same name
  • A Sixer is one of the senior youth members of a Cub Scout Pack, who leads a team called a "Six".