Harwell was a featured cast member in the sixth season of the VH1 reality show, The Surreal Life, in 2006. He has appeared on other television and radio shows, as well as making a cameo in the 2001 film Rat Race. On August 27, 2016, during a performance with Smash Mouth in Urbana, Illinois, Harwell collapsed on stage and was taken to a hospital by ambulance due to excessive drinking. The band proceeded to complete the concert without him.
Harwell's six-month-old son, Presley Scott Harwell, died in July 2001 from acute lymphatic leukemia. Subsequently, Harwell created a medical research fund in Presley's name.