Tyrese is a given name. Notable people with the name include:
- Tyrese Gibson, American Grammy nominated R&B singer-songwriter, actor, author, television producer
- Tyrese Rice, American professional basketball player
- Tyrese (album) - Tyrese Gibso's first album in 1998.
- Tyreese, a fictional character from the comic book series The Walking Dead; he's portrayed by Chad Coleman in the American television series of the same name