Vandalia may refer to:
- United States
- Vandalia, Illinois
- Vandalia, Indiana
- Vandalia, Michigan
- Vandalia, Missouri
- Vandalia, Montana
- Vandalia, Ohio
- Vandalia, West Virginia
- Vandalia (colony), a proposed British colony along the Ohio River in the 1770s
- USS Vandalia, four ships in the United States Navy
- Vandalia Gathering, an annual festival of traditional music and arts in Charleston, West Virginia
- Vandalia, an Argentinian manufacturer of swimwear and sportswear. The company also produces other products such as barrier cream, bags, shirts, shoes and other sports and clothing related goods.
- Vandalia Railroad, a former midwestern United States railroad. Acquired by the Pittsburgh, Cincinnati, Chicago and St. Louis Railroad on 1916/12/21 (effective 1917/01/01); both lines were major components in the former Pennsylvania Railroad empire.