- Xandra, a Dutch musical group fronted by Dutch singer Sandra Reemer representing Netherlands in the Eurovision Song Contest in 1979
- Xandra no Daibōken: Valkyrie to no Deai, (literally Xandra's Great Adventure: Encounter with the Valkyrie), an action-adventure platform game featuring character Krino Sandra (romanized as Xandra)
- Xandra, a character played by Sheryl Cruz in Komiks Presents: Varga
- Xandra, a fictional character in Doom 2099
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