In less than two months from the launch date, xoJane established itself as one of Forbes' "Top 10 Lifestyle Websites for Women." Pratt serves as editor-in-chief with Emily McCombs as executive editor, Lesley Kinzel as deputy editor and Mandy Stadtmiller as editor-at-large.
Pratt launched a British sister site, xojane.co.uk, in June 2012, with Rebecca Holman as editor.
In March 2013, xoJane launched spinoff beauty site xoVain.
xoJane contributor Amanda Lauren's piece "My Former Friend's Death Was a Blessing", in which she detailed her assumptions about her acquaintance's life and her reaction to her death, sparked public outcry. The article was removed by xoJane within a day.