xoJane (also known as xoJane.com) is an American online magazine geared toward women and founded by Jane Pratt, founding editor of Sassy and Jane magazines.

In less than two months from the launch date, xoJane established itself as one of Forbes' "Top 10 Lifestyle Websites for Women." Pratt serves as editor-in-chief with Emily McCombs as executive editor, Lesley Kinzel as deputy editor and Mandy Stadtmiller as editor-at-large.

Pratt launched a British sister site, xojane.co.uk, in June 2012, with Rebecca Holman as editor.

In March 2013, xoJane launched spinoff beauty site xoVain.

xoJane and xoVain were acquired by Time Inc. from Pratt and SAY Media in 2015.