XOXO may refer to:

  • Hugs and kisses, a way to express affection
  • XOXO (brand), a contemporary brand of clothing and accessories geared toward teenage girls
  • XOXO (festival), an arts and technology festival and conference held annually in September in Portland, Oregon
  • Santa Cruz Xoxocotlán, Mexico, commonly referred to as "Xoxo"
  • XOXO (microformat) or eXtensible Open XHTML Outlines, an XML microformat for outlines built on top of XHTML